Joint Neuroscience Events June 2013

Monday, June 10, 2013

Medical Sciences Building (MSB), University of Toronto
1 King's College Circle

Collaborative Program In Neuroscience (CPIN) Research Day

9:30   Pre-event Career Workshop (MSB 2172)
11:00 Meet with Workshop speakers (Stone Lobby)
11:30 Registration and poster set-up (Stone Lobby)
12:00 Opening remarks
12:15  poster presentation grouping, judges, and Rules of Poster Presentation Awards and Student’s Choice Awards

Pick-up Lunch
12:30 - 16:00 CPIN Poster Presentation and evaluation (Stone Lobby)
16:00 CPIN Group Photo
(Outside of MSB by J.J.R. MacLeod Auditorium)

Raymond and Beverly Sackler Distinguished Lecture (Macleod Auditorium)

16:30 Welcome remarks
16:45 Brian Kobilka (Stanford University, U.S.A.),
Structural Insights into the Dynamic Process of G-protein-coupled Receptor Activation

17:45 CPIN Poster presentation awards announcement
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Tuesday, June 11, 2013

International Symposium on Structural Neurobiology

Organized by Oliver Ernst, Canada Excellence Research Chair in Structural Neurobiology, University of Toronto

Room B-150  (1 floor below ground level)
Pharmacy Building, University of Toronto
144 College St.
9:00 - 10:30     Session 1
G-Protein Coupled Receptors (GPCRs)
Chair:  Brian Kobilka (Stanford University, U.S.A.),
9:00 Opening remarks
9:10 Scott Prosser (University of Toronto, Canada), GPCR Dynamics - Understanding the Role of Ligands on GPCR Activation by Using 19F NMR
9:35 Oliver Ernst (University of Toronto, Canada), Structural Insights into First Steps of Seeing
10:00 Dwayne Miller (University of Hamburg, Germany/University of Toronto, Canada), Rhodopsin Family of Sensory Proteins Breaks Speed Records – New Questions on the Role of Quantum Effects in Biology

10:35 - 11:00 Coffee Break

11:00 Tom Sakmar (Rockefeller University, New York, U.S.A.), Probing Receptor Activation with Genetically-Encoded Unnatural Amino Acids
11:35 John J. Irwin & Brian K. Shoichet (University of California, San Francisco, U.S.A./University of Toronto, Canada), Structure-Based and Chemoinformatics Discovery of GPCR Ligands and Pharmacology
12:05 - 14:00 Lunch and Poster Session
14:00 - 15:35 Session 2
Transporters and Ion channels
Chair: Reinhart Reithmeier (University of Toronto, Canada)
14:05 Da-Neng Wang (New York University School of Medicine, New York, U.S.A.), Structure and Mechanism of a Bacterial INDY Homolog — A Sodium-dependent Carboxylate Transporter Involved in Fatty Acid Synthesis and Obesity
14:40 Ernst Bamberg (Max Planck Institute of Biophysics, Frankfurt, Germany), Light-gated ion channels and pumps in optogenetics
15:15 Emil  Pai (University of Toronto, Canada), Analysis of the Bacterial Mg2+ Channel CorA in the Presence and Absence of Divalent Ions
15:40 - 16:00   Coffee Break
16:00 - 17:10 Session 3       
Approaches to Drug Discovery
Chair: Ruth Ross (University of Toronto, Canada)
16:05 Ron Dror (D.E. Shaw Research, New York, U.S.A.), How Drugs Bind and Control their Targets: Characterizing GPCR Signaling Through Atomic-level Simulation
16:40 Andrew Doré, Heptares Therapeutics Ltd (Welwyn Garden City, UK), StaR’s® and Structures: Enabling GPCR Drug Discovery

17:15 Closing remarks - end of the scientific meeting