"Protein Adsorption on a Degradable Polyurethane (D-PHI) Scaffold and Its Role in Human Monocyte and VSMC Interactions during Tissue Generation"

Professor Paul Santerre
Institute of Biomaterials and Biomedical Engineering, Faculty of Dentistry, University of Toronto
Friday, January 10, 2014 - 2:00pm
Ramsay Wright Building, Room 432
Departmental Seminar
Following the implantation of a biomaterial, monocytes play a critical role directing the subsequent cellular and wound healing response. These effects are orchestrated through a combination of released cytokines and regulatory growth factors, direct cell-cell contact between monocytes and other cell types, and protein interactions between the cells and the biomaterial substrates. Previous work evaluating the use of a degradable polar hydrophobic ionic polyurethane (D-PHI) for vascular tissue engineering applications indicated its ability to support an anti-inflammatory monocyte state while also supporting growth and a contractile vascular smooth muscle cell (VSMC) phenotype. The current presentation reports on the mechanisms of action by which the unique surface chemistry of D-PHI influences cell monocyte function via the adsorbed protein layer, in order to direct subsequent VSMC interactions with the scaffold during tissue generation.
Prof. Maurice Ringuette <maurice.ringuette@utoronto.ca>
Dept of Cell and Systems Biology