Keeping silent takes self-control: Maintenance of epigenetic stability through intrinsic enzyme autoregulation

Mark Currie, PhD
Cell and Systems Biology, University of Toronto - Mississauga
Friday, November 10, 2023 - 11:00am
Ramsay Wright Building, Room 432
Invited Speaker Seminar
Biological inheritance cannot be fully explained by genetics. Non-genetic, or epigenetic, mechanisms that are not encoded in the DNA sequence make important contributions to both the acquisition and transmission of traits. Histone posttranslational modifications including methylation, acetylation, and ubiquitylation, for instance, carry epigenetic information that is critical for both establishing and maintaining proper gene expression programs and cell identity. Histone and non-histone proteins package eukaryotic genomes into a complex called chromatin, which is a fundamental determinant of gene activity. Densely packed chromatin restricts access to DNA and is associated with inactive or silent parts of the genome, called heterochromatin. Whereas loose packaging facilitates access to DNA in active genomic regions, called euchromatin. My lab seeks to understand the mechanisms that govern genome organization, epigenetic gene regulation, and genome stability in health and disease. In my seminar, I will present the discovery of a novel autoregulatory mechanism in a conserved enzyme that mediates epigenetic gene silencing. I will also discuss our recent work on understanding the fundamental relationship between heterochromatin structure and function.
Arneet Saltzman
Dept of Cell and Systems Biology
Virtual Seminar ID: 
874 4742 2547
Virtual Seminar Password: