Computational Microscopy of SARS-CoV-2

I will discuss our lab’s efforts, together with collaborators, to understand the SARS-CoV-2 virus in atomic detail, with the goals to better understand molecular recognition of the virus and host cell receptors, antibody binding and design, and the search for novel therapeutics. I will focus on our studies of the spike protein, its glycan shield, its interactions with the human ACE2 receptor, our efforts to model the SARS-CoV-2 virion, and escape variants.