Role of Axin signaling in regulating lipid metabolism and lifespan in C. elegans

The C. elegans Axin family member, PRY-1, is a known component of the canonical Wnt signal transduction pathway. Earlier, my lab had demonstrated the critical role of PRY-1 in vulval development that involves interactions with Wnt and Notch pathway components. More recently, we have uncovered new functions of PRY-1 that include regulation of lipid metabolism and lifespan. The progress on these fronts will be presented.