Dr. Bin Tian
Rutgers New Jersey Medical School
Wednesday, February 6, 2019 - 11:00am
CCBR Red Room
Invited Speaker Seminar
Abstract:
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3ʹ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation. In this seminar, I will discuss mechanisms at molecular and systems levels that have been implicated in APA regulation under cell differentiation and stress conditions. I will also present our recent data aimed at understanding the consequences of APA in modulation of gene expression and mRNA metabolism.
Host:
Drs. Benjamin Blencowe and Quaid Morris
Department of Molecular Genetics
Poster: