Biological Networks at Atomic Resolution

Systems biology aims to build a working model of the cell by first mapping the network of interactions among proteins and other biomolecules in the cell. While highly successful, this network-based view of the cell treats biomolecules and their interactions as nodes and edges with little atomic details. Here, I will present recent work on constructing genome-scale structural models of nodes and edges within protein-protein interaction networks. I will show that this structural systems biology approach provides useful insights in evolutionary biophysics, species interaction, and human disease.