Molecular Medicine Research Connections

JOIN US for the next Research Connections seminar on Tuesday, March 25th from 12-1pm, when we are delighted to welcome: Benjamin Steinberg (Staff Anesthesiologist, Department of Anesthesia and Pain Medicine; Scientist in Neurosciences and Mental Health); and Blayne Sayed (Staff Surgeon, Division of General and Thoracic Surgery, Associate Scientist in Cell and Systems Biology) This focus of this Research Connections is The ins, outs and inhibition of NINJ1: Protecting against liver injury during transplant which will be followed by an open discussion with panelists Ori Scott and Neil Goldenberg. All are welcome to join us in-person in Event Rooms 2A/2B, 2nd floor of the PGCRL. The ins, outs, and inhibition of NINJ1: Protecting against liver injury during transplant NINJ1 is the terminal executioner of cell death pathways that culminate in plasma membrane rupture. Using clinical samples and preclinical models, we have been investigating how NINJ1 inhibition protects against liver injury during transplant. These translational studies are complemented by our investigation into the molecular mechanisms of NINJ1 activation and its mode of action. Together, our collaborative work aims to understand how cell death contributes to disease and develop strategies to preserve tissue integrity during solid organ transplantation.