Drosophila in disease diagnosis, mechanisms, and precision therapy: Loss of IRF2BPL impairs neuronal maintenance via excess Wnt signaling

Dr. Marcogliese investigates the genetic, molecular, and cellular mechanisms underlying neurological disease. Dr. Marcogliese uses multiple strategies in Drosophila to: 1) assess variant function, 2) uncover biological mechanisms, and 3) develop models for drug testing. His work has helped discover IRF2BPL as a causative gene in pediatric neuroregression and has implicated excess Wnt transcription and signalling in neurodegeneration. Dr. Paul Marcogliese is being interviewed as a candidate for the Scientist position in the Research Institute ________________________________________________________________________________