Chaperoning Histone H3: In Health and Disease'

Chromatin is assembled into repetitive units known as nucleosomes – each composed of histone proteins and DNA. Soluble histone pools are processed and maintained by histone chaperone proteins, prior to their deposition on DNA. Once on DNA, histones have a broad impact on chromatin structures and accessibility. The chaperoning of the H3.1 and H3.3 histone variants will be discussed, with a particular focus on the ATRX chromatin remodelling protein that helps deposit H3.3.