Dr. Ji-Young Youn
SickKids Research Institute
Thursday, June 11, 2020 - 11:00am
Zoom For access, please register in advance: https://zoom.us/meeting/register/tJElduhpjsvHtYNNi8dMwBlLG8SBLNYhCpN
Departmental Seminar
Abstract:
As a postdoctoral fellow in Dr. Anne-Claude Gingras’ lab, I utilized in vivo
proximity-dependent biotinylation assay (BioID) in human cells to systematically
survey the proteome architecture of two cytosolic membraneless organelles,
Stress Granules and P-bodies, and define their proteome (Mol. Cell; PMID:
29395067). Building upon this work, I propose to further investigate the molecular
interactions governing the organization and the dynamic properties of Stress
Granules, which are implicated in neurological disorder such as Amyotrophic
Lateral Sclerosis (ALS).
Host:
Dr. Leah Cowen
Department of Molecular Genetics