Revealing Host Pathogen Dynamics with the Next Generation of Systems Virology Approaches

Viruses are molecular machines evolved to exploit the specialized cellular niches of their hosts for replication. This co-dependency manifests itself in thousands of molecular changes that influence cellular function and may result in disease. A systematic, quantitative understanding of these changes is essential for the understanding of these disease states and for the development of next-generation therapeutics. Only recently, however, have technological advances in proteomics, functional genomics, and cellular engineering allowed for the generation of systems-level interaction maps in mammalian cells. By bridging these technological innovations to infectious disease, I strive to gain insight into the molecular mechanisms of health and pathogenesis.