Three stories about the cancer genome

I will discuss three stories about the cancer genome in relation to tumorigenesis, progression, and therapeutics. The first concerns a novel rearrangement in pediatric gliomas, and the complex mechanisms by which it promotes tumorigenesis. The second concerns the genetic changes endometrial cancers undergo as they progress from pre-invasive lesions to metastatic cancer. The third concerns vulnerabilities unveiled by cancer genome alterations that do not rely on targeting oncogenic pathways.