Folding and self-assembly of peptides and proteins in membranes

Régis Pomès
Program in Molecular Medicine Research Institute, The Hospital for Sick Children
Thursday, September 26, 2019 - 12:00pm
McLennan Physical Laboratories, Room MP606
Invited Speaker Seminar
Many biological processes of interest, such as ion and solute transport, bacterial infection, and immune response, are mediated by proteins embedded in biological membranes. However, elucidating the molecular factors underlying the interaction of proteins with lipid bilayers is challenging. Large-scale computing and efficient sampling methods make it possible to examine the structure and function of peptides and proteins in membranes at the atomic level of detail. I will present recent and ongoing molecular simulation studies aimed at characterizing the structural and physical basis for the solvation, folding, and self assembly of peptides and proteins in lipid membranes. Specifically, I will present studies of the selectivity and specificity of trans-membrane -helix association in the homotetrameric M2 channel of influenza A; the self assembly of peptides into -sheet oligomers linked to the toxicity of prion diseases; and the spontaneous formation of toroidal pores by bee venom peptide melittin.
Andrea Guljas
BiophysTO Lunchtime Talks