Network Effects on Cell Surface Receptor Function

Professor Adam Mott
Friday, September 21, 2018 - 11:00am
Ramsay Wright Building, Room 432
Departmental Seminar
To thrive, plants must be able to quickly recognize and respond to changing environmental conditions and pathogen attack. The perception of many signals is accomplished through the actions of members of the leucine-rich repeat receptor kinase (LRR-RK) family, of which there are 225 in Arabidopsis. Upon detection of an extracellular signal, these receptors physically interact to form signaling-competent structures able to integrate complex signals to guide plant defence and growth. Using a high-throughput interaction screen we determined the interactions between 200 of the LRR-RLKs from Arabidopsis. Using network analysis and community detection we have detected distinct, but interconnected, subnetworks that show evidence of specialization of biological activity and shown novel function for several previous unstudied receptors. In addition, we show that the overall network structure is critical for proper signaling responses, and disruptions can have unexpected consequences at a distance.
Professor Darrell Desveaux
Dept of Cell and Systems Biology