Targeting the undruggable: high-throughout inhibition of protein-protein interactions

I will present our advances in combining computational and experimental techniques to develop novel inhibitors. We have developed an integrated pipeline that first computationally designs large libraries of potential inhibitors and can then screen these for either cellular phenotype, affinity or other using cell sorting. I will showcase this pipeline on two example applications, first for developing inhibitors to protein-protein interactions and second for developing novel high-affinity biologics.